human PDE4B shRNA silencing AAV

Name
AAV-h-PDE4B-shRNA

Cat No
shAAV-218476

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDE4B.

shAAV-218476

AAV-h-PDE4B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE4B (phosphodiesterase 4B). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DPDE4; PDEIVB

Description (Vector)

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4B encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene ID

5142

Gene Name (Vector)

phosphodiesterase 4B

Gene Symbol

PDE4B

HGNC ID

HGNC:8781

ORF Size (aa)

2211

ORF Size (bp)

2211 bp

RefSeq ID

NM_002600

RefSeq Synonyms

NM_002600, NM_001297442, NM_001297441, NM_001297440, NM_001037341, NM_001037340, NM_001037339, BC105040, BC101480,

Species

human

UniGene ID

Hs.198072

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.