human PDE1A shRNA silencing AAV

Name
AAV-h-PDE1A-shRNA

Cat No
shAAV-218461

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDE1A.

shAAV-218461

AAV-h-PDE1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE1A (phosphodiesterase 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A

Description (Vector)

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 (PubMed 11342109); Fidock et al., 2002 (PubMed 11747989)).(supplied by OMIM, Oct 2009)

Gene ID

5136

Gene Name (Vector)

phosphodiesterase 1A

Gene Symbol

PDE1A

HGNC ID

HGNC:8774

ORF Size (aa)

1638

ORF Size (bp)

1638 bp

RefSeq ID

NM_001003683

RefSeq Synonyms

NM_005019, NM_001258314, NM_001258313, NM_001258312, NM_001003683, BC022480,

Species

human

UniGene ID

Hs.680373

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.