human PDE10A shRNA silencing AAV

Name
AAV-h-PDE10A-shRNA

Cat No
shAAV-218457

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDE10A.

shAAV-218457

AAV-h-PDE10A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE10A (phosphodiesterase 10A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A19

Description (Vector)

PDE10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.

Gene ID

10846

Gene Name (Vector)

phosphodiesterase 10A

Gene Symbol

PDE10A

HGNC ID

HGNC:8772

ORF Size (aa)

2340

ORF Size (bp)

2340 bp

RefSeq ID

NM_006661

RefSeq Synonyms

NM_006661, NM_001130690, BC104860, BC104858,

Species

human

UniGene ID

Hs.348762

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.