human PCSK4 shRNA silencing AAV

Name
AAV-h-PCSK4-shRNA

Cat No
shAAV-218412

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PCSK4.

shAAV-218412

AAV-h-PCSK4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCSK4 (proprotein convertase subtilisin/kexin type 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PC4; SPC5

Description (Vector)

PCSK4 encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II.

Gene ID

54760

Gene Name (Vector)

proprotein convertase subtilisin/kexin type 4

Gene Symbol

PCSK4

HGNC ID

HGNC:8746

ORF Size (aa)

2268

ORF Size (bp)

2268 bp

RefSeq ID

NM_017573

RefSeq Synonyms

NM_017573, BC167771,

Species

human

UniGene ID

Hs.46884

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.