human PBK shRNA silencing AAV

Name
AAV-h-PBK-shRNA

Cat No
shAAV-218285

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PBK.

shAAV-218285

AAV-h-PBK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PBK (PDZ binding kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cancer/testis antigen 84; CT84; epididymis luminal protein 164; HEL164; lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; serine/threonine protein kinase; spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; TOPK

Description (eCommerce)

PBK (PDZ binding kinase), also known as TOPK (T-LAK cell-originated protein), is a mitogen-activated protein kinase kinase (MAPKK) first identified in a yeast two-hybrid assay as a Dlg1 (disks-large)-interacting protein. PBK has been found to be up-regulated in breast cancers and highly expressed in neural stem cell cultures.

Description (Vector)

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene ID

55872

Gene Name (eCommerce)

PDZ binding kinase

Gene Name (Vector)

PDZ binding kinase

Gene Symbol

PBK

HGNC ID

HGNC:18282

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

969

Protein Name (eCommerce)

Lymphokine-activated killer T-cell-originated protein kinase

RefSeq ID

NM_018492

RefSeq Synonyms

NM_018492, NM_001278945, BC015191,

Research Areas

Cell Cycle,Kinase/Phosphatase,Signal Transduction

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,signal_transduction

Species

human

Target Sentence

PBK (PDZ binding kinase), also known as TOPK (T-LAK cell-originated protein), is a mitogen-activated protein kinase kinase (MAPKK) first identified in a yeast two-hybrid assay as a Dlg1 (disks-large)-interacting protein. PBK has been found to be up-regulated in breast cancers and highly expressed in neural stem cell cultures.

UniGene ID

Hs.104741

UniProt ID (eCommerce)

Q96KB5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.