human PARK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PARK2.
shAAV-218225
AAV-h-PARK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PARK2 (parkin RBR E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AR-JP; LPRS2; PDJ; PRKN
Description (Vector)
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Gene ID
5071
Gene Name (Vector)
parkin RBR E3 ubiquitin protein ligase
Gene Symbol
PARK2
HGNC ID
HGNC:8607
ORF Size (aa)
1164
RefSeq ID
NM_013988
RefSeq Synonyms
NM_013988, NM_013987, NM_004562, BC022014,
Species
human
UniGene ID
Hs.716168
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.