human NXN shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NXN.
shAAV-217286
AAV-h-NXN-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NXN (nucleoredoxin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NRX; nucleoredoxin; nucleoredoxin 1; TRG-4
Description (eCommerce)
Nucleoredoxin/NXN functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Nucleoredoxin/NXN may also function as a transcriptional regulator of protein phosphatase 2A (PP2A) (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKJ4].
Gene ID
64359
Gene Name (eCommerce)
nucleoredoxin
Gene Name (Vector)
nucleoredoxin
Gene Symbol
NXN
HGNC ID
HGNC:18008
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1308
ORF Size (bp)
1308 bp
Protein Name (eCommerce)
Nucleoredoxin
RefSeq ID
NM_022463
RefSeq Synonyms
NM_022463, NM_001205319, BC153025, BC152722,
Research Areas
Cardiology,Cardiovascular,Immunology,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cardiovascular,immunology,signal_transduction
Species
human
Target Sentence
Nucleoredoxin/NXN functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Nucleoredoxin/NXN may also function as a transcriptional regulator of protein phosphatase 2A (PP2A) (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKJ4].
UniGene ID
Hs.527989
UniProt ID (eCommerce)
Q6DKJ4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.