human NUP43 shRNA silencing AAV

Name
AAV-h-NUP43-shRNA

Cat No
shAAV-217247

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NUP43.

shAAV-217247

AAV-h-NUP43-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUP43 (nucleoporin 43). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA350J20.1; nucleoporin 43kDa; nucleoporin Nup43; nup107-160 subcomplex subunit Nup43; p42

Description (eCommerce)

Nucleoporin 43 (NUP43) is a component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y221].

Description (Vector)

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 (PubMed 15146057)).(supplied by OMIM, Mar 2008)

Gene ID

348995

Gene Name (eCommerce)

nucleoporin 43

Gene Name (Vector)

nucleoporin 43

Gene Symbol

NUP43

HGNC ID

HGNC:21182

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1143

ORF Size (bp)

1143 bp

Protein Name (eCommerce)

Nucleoporin Nup43

RefSeq ID

NM_198887

RefSeq Synonyms

NM_198887, BC065028,

Research Areas

Cell Cycle,Cell Division,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Transport

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism

Species

human

Target Sentence

Nucleoporin 43 (NUP43) is a component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y221].

UniGene ID

Hs.510375

UniProt ID (eCommerce)

Q8NFH3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.