human NUDT1 shRNA silencing AAV

Name
AAV-h-NUDT1-shRNA

Cat No
shAAV-217198

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NUDT1.

shAAV-217198

AAV-h-NUDT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUDT1 (nudix hydrolase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MTH1

Description (Vector)

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene ID

4521

Gene Name (Vector)

nudix hydrolase 1

Gene Symbol

NUDT1

HGNC ID

HGNC:8048

ORF Size (aa)

471

RefSeq ID

NM_002452

RefSeq Synonyms

NM_198954, NM_198953, NM_198952, NM_198950, NM_198949, NM_198948, NM_002452, BC065367, BC051375, BC040144, BC014618,

Species

human

UniGene ID

Hs.534331

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.