human NUDCD3 shRNA silencing AAV

Name 
AAV-h-NUDCD3-shRNA
Cat No 
shAAV-217195
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NUDCD3.

shAAV-217195
AAV-h-NUDCD3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUDCD3 (NudC domain containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
nudC domain-containing protein 3; NudCL; NudC-like protein
Description (eCommerce)
NudC domain-containing protein 3 (NUDCD3) functions to maintain the stability of dynein intermediate chain. Depletion NUDCD3 results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition [taken from NCBI Entrez Gene (Gene ID: 23386)].
Description (Vector)
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.
Gene ID
23386
Gene Name (eCommerce)
NudC domain containing 3
Gene Name (Vector)
NudC domain containing 3
Gene Symbol
NUDCD3
HGNC ID
HGNC:22208
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1086
Protein Name (eCommerce)
NudC domain-containing protein 3
RefSeq ID
NM_015332
RefSeq Synonyms
NM_015332, BC035014, BC003691,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
NudC domain-containing protein 3 (NUDCD3) functions to maintain the stability of dynein intermediate chain. Depletion NUDCD3 results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition [taken from NCBI Entrez Gene (Gene ID: 23386)].
UniGene ID
Hs.488171
UniProt ID (eCommerce)
Q8IVD9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.