human NR1I3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NR1I3.
shAAV-217043
AAV-h-NR1I3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NR1I3 (nuclear receptor subfamily 1 group I member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAR; CAR1; MB67
Description (Vector)
NR1I3 encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9970
Gene Name (Vector)
nuclear receptor subfamily 1 group I member 3
Gene Symbol
NR1I3
HGNC ID
HGNC:7969
ORF Size (aa)
825
RefSeq ID
NM_005122
RefSeq Synonyms
NM_005122, NM_001077482, NM_001077481, NM_001077480, NM_001077479, NM_001077478, NM_001077477, NM_001077476, NM_001077475, NM_001077474, NM_001077473, NM_001077472, NM_001077471, NM_001077470, NM_001077469, BC121121, BC121120, BC069651, BC069626,
Species
human
UniGene ID
Hs.349642
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.