human NR0B1 shRNA silencing AAV

Name
AAV-h-NR0B1-shRNA

Cat No
shAAV-217025

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NR0B1.

shAAV-217025

AAV-h-NR0B1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NR0B1 (nuclear receptor subfamily 0 group B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AHC; AHCH; AHX; DAX-1; DAX1; DSS; GTD; HHG; NROB1; SRXY2

Description (Vector)

NR0B1 encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

Gene ID

190

Gene Name (Vector)

nuclear receptor subfamily 0 group B member 1

Gene Symbol

NR0B1

HGNC ID

HGNC:7960

ORF Size (aa)

1413

ORF Size (bp)

1413 bp

RefSeq ID

NM_000475

RefSeq Synonyms

NM_000475, BC011564,

Species

human

UniGene ID

Hs.268490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.