human NPR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NPR1.
shAAV-216997
AAV-h-NPR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NPR1 (natriuretic peptide receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ANPa; ANPRA; GUC2A; GUCY2A; NPRA
Description (Vector)
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 (PubMed 7982997)). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).(supplied by OMIM, May 2009)
Gene ID
4881
Gene Name (Vector)
natriuretic peptide receptor 1
Gene Symbol
NPR1
HGNC ID
HGNC:7943
ORF Size (aa)
3186
ORF Size (bp)
3186 bp
RefSeq ID
NM_000906
RefSeq Synonyms
NM_000906, BC063304,
Species
human
UniGene ID
Hs.490330
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.