human NPPA shRNA silencing AAV

Name
AAV-h-NPPA-shRNA

Cat No
shAAV-216992

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NPPA.

shAAV-216992

AAV-h-NPPA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPPA (natriuretic peptide A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; PND

Description (Vector)

NPPA belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.

Gene ID

4878

Gene Name (Vector)

natriuretic peptide A

Gene Symbol

NPPA

HGNC ID

HGNC:7939

ORF Size (aa)

462

RefSeq ID

NM_006172

RefSeq Synonyms

NM_006172, BC005893,

Species

human

UniGene ID

Hs.75640

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.