human NPHP4 shRNA silencing AAV

Name
AAV-h-NPHP4-shRNA

Cat No
shAAV-216960

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NPHP4.

shAAV-216960

AAV-h-NPHP4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPHP4 (nephrocystin 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

POC10; SLSN4

Description (Vector)

NPHP4 encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa.

Gene ID

261734

Gene Name (Vector)

nephrocystin 4

Gene Symbol

NPHP4

HGNC ID

HGNC:19104

ORF Size (aa)

2736

ORF Size (bp)

2736 bp

RefSeq ID

NM_015102

RefSeq Synonyms

NM_015102, NM_001291594, NM_001291593, BC040520,

Species

human

UniGene ID

Hs.462348

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.