human ATM shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ATM.
shAAV-216937
AAV-h-ATM-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ATM (ATM serine/threonine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AT mutated; A-T mutated; AT1; ATA; ataxia telangiectasia mutated; ATC; ATD; ATDC; ATE; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Description (eCommerce)
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.
Description (Vector)
ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Gene ID
472
Gene Name (eCommerce)
ATM serine/threonine kinase
Gene Name (Vector)
ATM serine/threonine kinase
Gene Symbol
ATM
HGNC ID
HGNC:795
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5127
ORF Size (bp)
5127 bp
Protein Name (eCommerce)
Serine-protein kinase ATM
RefSeq ID
NM_000051
RefSeq Synonyms
NM_000051, BC137169, BC061584, BC022307,
Research Areas
Aging,Apoptosis,Brain Development,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cell Division,DNA Damage/Repair,Fanconi anemia,Glioma,Homologous Recombination,Host-Virus Interactions,Hypoxia,Immunology,Kinase/Phosphatase,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,Neurodegeneration,Neurodevelopment,NF-kB Signaling,p53 Signaling,Prostate Cancer,RNA Processing,Signal Transduction,Telomeric Maintenance,Transcriptional Misregulation in Cancer,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.
UniGene ID
Hs.367437
UniProt ID (eCommerce)
Q13315
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.