human ATM shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-216937
Availability:
3-5 weeks
Name:
Ad-h-ATM-shRNA
This is an Adenovirus expressing shRNA for silencing of Human ATM.
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Product Info
- Knockdown
- >60% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ATM
- Gene Name
- ATM serine/threonine kinase
- Gene ID
- 472
- Gene Synonyms
- AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
- ORF Size
- 5127 bp
- RefSeq#
- NM_000051
- Gene Description
- ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
- UniGene ID
- Hs.367437
- HGNC ID
- HGNC:795
Related Products
Product | Cat No. |
---|---|
Ad-ATM | 1491 |
Ad-h-ATM | ADV-216937 |
AAV-h-ATM-shRNA | shAAV-216937 |
AAV-m-ATM-shRNA | shAAV-253237 |
Ad-m-ATM-shRNA | shADV-253237 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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