human NOS1 shRNA silencing AAV

Name
AAV-h-NOS1-shRNA

Cat No
shAAV-216900

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NOS1.

shAAV-216900

AAV-h-NOS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOS1 (nitric oxide synthase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS

Description (Vector)

NOS1 belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Gene ID

4842

Gene Name (Vector)

nitric oxide synthase 1

Gene Symbol

NOS1

HGNC ID

HGNC:7872

ORF Size (aa)

4302

ORF Size (bp)

4302 bp

RefSeq ID

NM_000620

RefSeq Synonyms

NM_001204218, NM_001204214, NM_001204213, NM_000620, BC172474, BC156399,

Species

human

UniGene ID

Hs.654410

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.