human NOP10 shRNA silencing AAV

Name
AAV-h-NOP10-shRNA

Cat No
shAAV-216883

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NOP10.

shAAV-216883

AAV-h-NOP10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOP10 (NOP10 ribonucleoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DKCB1; NOLA3; NOP10P

Description (Vector)

NOP10 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. NOP10 encodes a protein related to Saccharomyces cerevisiae Nop10p.

Gene ID

55505

Gene Name (Vector)

NOP10 ribonucleoprotein

Gene Symbol

NOP10

HGNC ID

HGNC:14378

ORF Size (aa)

195

RefSeq ID

NM_018648

RefSeq Synonyms

NM_018648, BC063023, BC008886,

Species

human

UniGene ID

Hs.14317

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.