human NOL8 shRNA silencing AAV

Name 
AAV-h-NOL8-shRNA
Cat No 
shAAV-216868
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NOL8.

shAAV-216868
AAV-h-NOL8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOL8 (nucleolar protein 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bA62C3.3; bA62C3.4; C9orf34; NOP132; nucleolar protein 8; nucleolar protein Nop132
Description (eCommerce)
Nucleolar protein 132 (NOP132) was identified as a protein that interacts with the G protein, RRAG A (RAG A)/GTR1p, a member of the Ras-like small G protein family. NOP132 has been shown to interact mainly with proteins involved in ribosome biogenesis such as DDX47. NOP132 may play a role in recruiting pre-RNA processing proteins to regions of rRNA transcription in the nucleus.
Description (Vector)
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 (PubMed 14660641)).(supplied by OMIM, Mar 2008)
Gene ID
55035
Gene Name (eCommerce)
nucleolar protein 8
Gene Name (Vector)
nucleolar protein 8
Gene Symbol
NOL8
HGNC ID
HGNC:23387
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3300
ORF Size (bp)
3300 bp
Protein Name (eCommerce)
Nucleolar protein 8
RefSeq ID
NM_017948
RefSeq Synonyms
NM_017948, NM_001330722, NM_001256394, BC146810,
Research Areas
Cell Cycle,DNA Replication,Replication,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Nucleolar protein 132 (NOP132) was identified as a protein that interacts with the G protein, RRAG A (RAG A)/GTR1p, a member of the Ras-like small G protein family. NOP132 has been shown to interact mainly with proteins involved in ribosome biogenesis such as DDX47. NOP132 may play a role in recruiting pre-RNA processing proteins to regions of rRNA transcription in the nucleus.
UniGene ID
Hs.442199
UniProt ID (eCommerce)
Q76FK4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.