human NME1 shRNA silencing AAV

Name
AAV-h-NME1-shRNA

Cat No
shAAV-216817

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NME1.

shAAV-216817

AAV-h-NME1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NME1 (NME/NM23 nucleoside diphosphate kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1

Description (Vector)

NME1 (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Gene ID

4830

Gene Name (Vector)

NME/NM23 nucleoside diphosphate kinase 1

Gene Symbol

NME1

HGNC ID

HGNC:7849

ORF Size (aa)

459

RefSeq ID

NM_000269

RefSeq Synonyms

NM_198175, NM_000269, BC018994, BC000293,

Species

human

UniGene ID

Hs.463456

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.