human NLRP13 shRNA silencing AAV

Name
AAV-h-NLRP13-shRNA

Cat No
shAAV-216795

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NLRP13.

shAAV-216795

AAV-h-NLRP13-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLRP13 (NLR family pyrin domain containing 13). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLR19.7; NALP13; NOD14; PAN13

Description (Vector)

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)

Gene ID

126204

Gene Name (Vector)

NLR family pyrin domain containing 13

Gene Symbol

NLRP13

HGNC ID

HGNC:22937

ORF Size (aa)

3129

ORF Size (bp)

3129 bp

RefSeq ID

NM_176810

RefSeq Synonyms

NM_176810, NM_001321057, BC148742, BC146295,

Species

human

UniGene ID

Hs.446924

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.