human NKX2-5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NKX2-5.
shAAV-216765
AAV-h-NKX2-5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NKX2-5 (NK2 homeobox 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHNG5; CSX; CSX1; HLHS2; NKX2.5; NKX2E; NKX4-1; VSD3
Description (Vector)
NKX2-5 encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
Gene ID
1482
Gene Name (Vector)
NK2 homeobox 5
Gene Symbol
NKX2-5
HGNC ID
HGNC:2488
ORF Size (aa)
975
ORF Size (bp)
975 bp
RefSeq ID
NM_004387
RefSeq Synonyms
NM_004387, NM_001166176, NM_001166175, BC025711,
Species
human
UniGene ID
Hs.54473
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.