human NFASC shRNA silencing AAV

Name 
AAV-h-NFASC-shRNA
Cat No 
shAAV-216625
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NFASC.

shAAV-216625
AAV-h-NFASC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NFASC (neurofascin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NF; NRCAML
Description (Vector)
NFASC encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. NFASC undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
Gene ID
23114
Gene Name (Vector)
neurofascin
Gene Symbol
NFASC
HGNC ID
HGNC:29866
ORF Size (aa)
3510
ORF Size (bp)
3510 bp
RefSeq ID
NM_001005388
RefSeq Synonyms
NM_015090, NM_001160333, NM_001160332, NM_001160331, NM_001005389, NM_001005388, BC137013,
Species
human
UniGene ID
Hs.13349

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.