human NEIL2 shRNA silencing AAV

Name
AAV-h-NEIL2-shRNA

Cat No
shAAV-216564

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NEIL2.

shAAV-216564

AAV-h-NEIL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NEIL2 (nei like DNA glycosylase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NEH2; NEI2

Description (Vector)

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226))(supplied by OMIM, Mar 2008)

Gene ID

252969

Gene Name (Vector)

nei like DNA glycosylase 2

Gene Symbol

NEIL2

HGNC ID

HGNC:18956

ORF Size (aa)

999

ORF Size (bp)

999 bp

RefSeq ID

NM_145043

RefSeq Synonyms

NM_145043, NM_001135748, NM_001135747, NM_001135746, BC013964, BC013952,

Species

human

UniGene ID

Hs.293818

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.