human NDUFS1 shRNA silencing AAV

Name
AAV-h-NDUFS1-shRNA

Cat No
shAAV-216520

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NDUFS1.

shAAV-216520

AAV-h-NDUFS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CI-75k; CI-75Kd; PRO1304

Description (Vector)

NDUFS1 belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

4719

Gene Name (Vector)

NADH:ubiquinone oxidoreductase core subunit S1

Gene Symbol

NDUFS1

HGNC ID

HGNC:7707

ORF Size (aa)

2184

ORF Size (bp)

2184 bp

RefSeq ID

NM_005006

RefSeq Synonyms

NM_005006, NM_001199984, NM_001199983, NM_001199982, NM_001199981, BC030833, BC022368, BC012068,

Species

human

UniGene ID

Hs.471207

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.