human MYBL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MYBL2.
shAAV-216121
AAV-h-MYBL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MYBL2 (MYB proto-oncogene like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BMYB; B-MYB; myb-like protein 2; myb-related protein B; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
Description (eCommerce)
B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.
Description (Vector)
MYBL2, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
Gene ID
4605
Gene Name (eCommerce)
MYB proto-oncogene like 2
Gene Name (Vector)
MYB proto-oncogene like 2
Gene Symbol
MYBL2
HGNC ID
HGNC:7548
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2103
ORF Size (bp)
2103 bp
Protein Name (eCommerce)
Myb-related protein B
RefSeq ID
NM_002466
RefSeq Synonyms
NM_002466, NM_001278610, BC053555, BC007585,
Research Areas
Cancer,Cell Cycle,EGFR Signaling,Host-Virus Interactions,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,infectious_disease,genetics,transcription_translation
Species
human
Target Sentence
B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.
UniGene ID
Hs.179718
UniProt ID (eCommerce)
P10244
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.