human MUTYH shRNA silencing AAV

Name
AAV-h-MUTYH-shRNA

Cat No
shAAV-216092

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MUTYH.

shAAV-216092

AAV-h-MUTYH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MUTYH (mutY DNA glycosylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MYH

Description (Vector)

MUTYH encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

4595

Gene Name (Vector)

mutY DNA glycosylase

Gene Symbol

MUTYH

HGNC ID

HGNC:7527

ORF Size (aa)

1608

ORF Size (bp)

1608 bp

RefSeq ID

NM_012222

RefSeq Synonyms

NM_012222, NM_001293196, NM_001293195, NM_001293192, NM_001293191, NM_001293190, NM_001128425, NM_001048174, NM_001048173, NM_001048172, NM_001048171, BC003178,

Species

human

UniGene ID

Hs.271353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.