human MTUS1 shRNA silencing AAV

Name
AAV-h-MTUS1-shRNA

Cat No
shAAV-216059

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MTUS1.

shAAV-216059

AAV-h-MTUS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MTUS1 (microtubule associated tumor suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2 receptor-interacting protein; AT2R binding protein; ATBP; ATIP; ATIP3; erythroid differentiation-related; ICIS; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1; Mitochondrial tumor suppressor 1; mitochondrial tumor suppressor gene 1; MP44; MTSG1; transcription factor MTSG1

Description (eCommerce)

The gene for the mitochondrial tumor suppressor 1 (MTUS1) was identified in a chromosomal region frequently deleted in epithelial cancers.

Description (Vector)

MTUS1 encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

Gene ID

57509

Gene Name (eCommerce)

microtubule associated scaffold protein 1

Gene Name (Vector)

microtubule associated tumor suppressor 1

Gene Symbol

MTUS1

HGNC ID

HGNC:29789

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3813

ORF Size (bp)

3813 bp

Protein Name (eCommerce)

Microtubule-associated tumor suppressor 1

RefSeq ID

NM_001001924

RefSeq Synonyms

NM_020749, NM_001330470, NM_001166393, NM_001001931, NM_001001925, NM_001001924, BC140068, BC140067, BC136320, BC033842,

Research Areas

Cancer,Cell Cycle,Cytoskeleton,Golgi Apparatus,Mitochondrion,Neurobiology,Signal Transduction,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,genetics,neurobiology,signal_transduction

Species

human

Target Sentence

The gene for the mitochondrial tumor suppressor 1 (MTUS1) was identified in a chromosomal region frequently deleted in epithelial cancers.

UniGene ID

Hs.7946

UniProt ID (eCommerce)

Q9ULD2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.