human MTRR shRNA silencing AAV

Name
AAV-h-MTRR-shRNA

Cat No
shAAV-216052

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MTRR.

shAAV-216052

AAV-h-MTRR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cblE; MSR

Description (Vector)

Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene ID

4552

Gene Name (Vector)

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Gene Symbol

MTRR

HGNC ID

HGNC:7473

ORF Size (aa)

2097

ORF Size (bp)

2097 bp

RefSeq ID

NM_002454

RefSeq Synonyms

NM_024010, NM_002454, BC109216, BC054816,

Species

human

UniGene ID

Hs.481551

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.