human MSR1 shRNA silencing AAV

Name
AAV-h-MSR1-shRNA

Cat No
shAAV-215927

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MSR1.

shAAV-215927

AAV-h-MSR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MSR1 (macrophage scavenger receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD204; phSR1; phSR2; SCARA1; SR-A; SRA

Description (Vector)

MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gene ID

4481

Gene Name (Vector)

macrophage scavenger receptor 1

Gene Symbol

MSR1

HGNC ID

HGNC:7376

ORF Size (aa)

1356

ORF Size (bp)

1356 bp

RefSeq ID

NM_002445

RefSeq Synonyms

NM_138716, NM_138715, NM_002445, BC063878,

Species

human

UniGene ID

Hs.147635

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.