human MLLT1 shRNA silencing AAV

Name 
AAV-h-MLLT1-shRNA
Cat No 
shAAV-215523
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MLLT1.

shAAV-215523
AAV-h-MLLT1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MLLT1 (MLLT1, super elongation complex subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CTC-503J8.6; ENL; ENL/MLL fusion; LTG19; MLL/ENL fusion protein; MLLT1/MLL fusion; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; protein ENL; YEATS domain-containing protein 1; YEATS1
Description (eCommerce)
MLLT1, also known as ENL (eleven nineteen leukemia protein), was originally identified as a gene involved in a recurrent translocation (11;19) with the mixed-lineage leukemia (MLL) gene. The MLL-ENL fusion protein has been found to associate with SWI/SNF complexes and promote transcription from the HoxA7 promoter. Additionally, from studies to identify proteins that associate with MLLT1, MLLT1 is suggested to play a role in histone modification and transcriptional elongation.
Gene ID
4298
Gene Name (eCommerce)
MLLT1, super elongation complex subunit
Gene Name (Vector)
MLLT1, super elongation complex subunit
Gene Symbol
MLLT1
HGNC ID
HGNC:7134
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1677
ORF Size (bp)
1677 bp
Protein Name (eCommerce)
Protein ENL
RefSeq ID
NM_005934
RefSeq Synonyms
NM_005934, BC148806, BC146385, BC146318,
Research Areas
Cancer,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
MLLT1, also known as ENL (eleven nineteen leukemia protein), was originally identified as a gene involved in a recurrent translocation (11;19) with the mixed-lineage leukemia (MLL) gene. The MLL-ENL fusion protein has been found to associate with SWI/SNF complexes and promote transcription from the HoxA7 promoter. Additionally, from studies to identify proteins that associate with MLLT1, MLLT1 is suggested to play a role in histone modification and transcriptional elongation.
UniGene ID
Hs.10095
UniProt ID (eCommerce)
Q03111

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.