human MCCC2 shRNA silencing AAV

Name
AAV-h-MCCC2-shRNA

Cat No
shAAV-215160

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MCCC2.

shAAV-215160

AAV-h-MCCC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MCCC2 (methylcrotonoyl-CoA carboxylase 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MCCB

Description (Vector)

MCCC2 encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

Gene ID

64087

Gene Name (Vector)

methylcrotonoyl-CoA carboxylase 2

Gene Symbol

MCCC2

HGNC ID

HGNC:6937

ORF Size (aa)

1692

ORF Size (bp)

1692 bp

RefSeq ID

NM_022132

RefSeq Synonyms

NM_022132, BC065027, BC014897,

Species

human

UniGene ID

Hs.604789

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.