human MAPKSP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LAMTOR3.
shAAV-215007
AAV-h-MAPKSP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
Description (Vector)
LAMTOR3 encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
Gene ID
8649
Gene Name (Vector)
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Gene Symbol
LAMTOR3
HGNC ID
HGNC:15606
ORF Size (aa)
375
RefSeq ID
NM_021970
RefSeq Synonyms
NM_021970, NM_001243736, BC026245,
Species
human
UniGene ID
Hs.716375
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.