human MAPK9 shRNA silencing AAV

Name
AAV-h-MAPK9-shRNA

Cat No
shAAV-214994

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MAPK9.

shAAV-214994

AAV-h-MAPK9-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MAPK9 (mitogen-activated protein kinase 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a

Description (Vector)

MAPK9 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene ID

5601

Gene Name (Vector)

mitogen-activated protein kinase 9

Gene Symbol

MAPK9

HGNC ID

HGNC:6886

ORF Size (aa)

1275

ORF Size (bp)

1275 bp

RefSeq ID

NM_139069

RefSeq Synonyms

NM_139070, NM_139069, NM_139068, NM_002752, NM_001308244, NM_001135044, BC032539,

Species

human

UniGene ID

Hs.484371

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.