human M6PR shRNA silencing AAV

Name
AAV-h-M6PR-shRNA

Cat No
shAAV-214761

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human M6PR.

shAAV-214761

AAV-h-M6PR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human M6PR (mannose-6-phosphate receptor, cation dependent). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD-M6PR; CD-MPR; MPR 46; MPR-46; MPR46; SMPR

Description (Vector)

M6PR encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

Gene ID

4074

Gene Name (Vector)

mannose-6-phosphate receptor, cation dependent

Gene Symbol

M6PR

HGNC ID

HGNC:6752

ORF Size (aa)

834

ORF Size (bp)

834 bp

RefSeq ID

NM_002355

RefSeq Synonyms

NM_002355, NM_001207024, BC024206,

Species

human

UniGene ID

Hs.134084

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.