human LTC4S shRNA silencing AAV

Name
AAV-h-LTC4S-shRNA

Cat No
shAAV-214668

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human LTC4S.

shAAV-214668

AAV-h-LTC4S-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LTC4S (leukotriene C4 synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.

Gene ID

4056

Gene Name (Vector)

leukotriene C4 synthase

Gene Symbol

LTC4S

HGNC ID

HGNC:6719

ORF Size (aa)

453

RefSeq ID

NM_145867

RefSeq Synonyms

NM_145867, BC029498,

Species

human

UniGene ID

Hs.706741

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.