human LTA shRNA silencing AAV

Name
AAV-h-LTA-shRNA

Cat No
shAAV-214657

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human LTA.

shAAV-214657

AAV-h-LTA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LTA (lymphotoxin alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LT; TNFB; TNFSF1; TNLG1E

Description (Vector)

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.

Gene ID

4049

Gene Name (Vector)

lymphotoxin alpha

Gene Symbol

LTA

HGNC ID

HGNC:6709

ORF Size (aa)

618

RefSeq ID

NM_000595

RefSeq Synonyms

NM_001159740, NM_000595, BC034729,

Species

human

UniGene ID

Hs.36

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.