human LRRC8A shRNA silencing AAV

Name 
AAV-h-LRRC8A-shRNA
Cat No 
shAAV-214592
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LRRC8A.

shAAV-214592
AAV-h-LRRC8A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LRRC8A (leucine rich repeat containing 8 family member A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AGM5; leucine rich repeat containing 8 family member A; leucine-rich repeat-containing protein 8A; LRRC8; SWELL1; swelling protein 1; volume-regulated anion channel subunit LRRC8A
Description (eCommerce)
LRRC8A belongs to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in the LRRC8A gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation [taken from NCBI Entrez Gene (Gene ID: 56262)].
Description (Vector)
LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Gene ID
56262
Gene Name (eCommerce)
leucine rich repeat containing 8 VRAC subunit A
Gene Name (Vector)
leucine rich repeat containing 8 family member A
Gene Symbol
LRRC8A
HGNC ID
HGNC:19027
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2433
ORF Size (bp)
2433 bp
Protein Name (eCommerce)
Volume-regulated anion channel subunit LRRC8A
RefSeq ID
NM_019594
RefSeq Synonyms
NM_019594, NM_001127245, NM_001127244, BC051322,
Research Areas
Immunology
Research Areas (Faceted)
immunology
Species
human
Target Sentence
LRRC8A belongs to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in the LRRC8A gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation [taken from NCBI Entrez Gene (Gene ID: 56262)].
UniGene ID
Hs.643600
UniProt ID (eCommerce)
Q8IWT6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.