human LOXL2 shRNA silencing AAV

Name
AAV-h-LOXL2-shRNA

Cat No
shAAV-214438

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human LOXL2.

shAAV-214438

AAV-h-LOXL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LOXL2 (lysyl oxidase like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LOR2; WS9-14

Description (Vector)

LOXL2 encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Gene ID

4017

Gene Name (Vector)

lysyl oxidase like 2

Gene Symbol

LOXL2

HGNC ID

HGNC:6666

ORF Size (aa)

2325

ORF Size (bp)

2325 bp

RefSeq ID

NM_002318

RefSeq Synonyms

NM_002318, BC000594,

Species

human

UniGene ID

Hs.661130

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.