human CCBP2 shRNA silencing AAV

Name
AAV-h-CCBP2-shRNA

Cat No
shAAV-214392

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACKR2.

shAAV-214392

AAV-h-CCBP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACKR2 (atypical chemokine receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CCBP2; CCR10; CCR9; CMKBR9; D6; hD6

Description (Vector)

CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. CCBP2 is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. CCBP2 is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Gene ID

1238

Gene Name (Vector)

atypical chemokine receptor 2

Gene Symbol

ACKR2

HGNC ID

HGNC:1565

ORF Size (aa)

1155

ORF Size (bp)

1155 bp

RefSeq ID

NM_001296

RefSeq Synonyms

NM_001296, BC112045, BC101629, BC020558, BC011631, BC008816,

Species

human

UniGene ID

Hs.146346

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.