human PARG shRNA silencing AAV

Name
AAV-h-PARG-shRNA

Cat No
shAAV-214352

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PARG.

shAAV-214352

AAV-h-PARG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PARG (poly(ADP-ribose) glycohydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

60

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

mitochondrial poly(ADP-ribose) glycohydrolase; PARG99; poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform

Description (eCommerce)

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. PARG is found in many tissues and may be subject to proteolysis generating smaller, active products [taken from NCBI Entrez Gene (Gene ID: 8505)].

Description (Vector)

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Gene ID

8505

Gene Name (eCommerce)

poly(ADP-ribose) glycohydrolase

Gene Name (Vector)

poly(ADP-ribose) glycohydrolase

Gene Symbol

PARG

HGNC ID

HGNC:8605

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2931

ORF Size (bp)

2931 bp

Protein Name (eCommerce)

Poly(ADP-ribose) glycohydrolase

RefSeq ID

NM_003631

RefSeq Synonyms

NM_003631, NM_001324381, NM_001303489, NM_001303487, NM_001303486, BC052966, BC050560,

Research Areas

DNA Damage/Repair,Metabolism/Metabolic Process,Mitochondrion

Research Areas (Faceted)

genetics,transcription_translation,metabolism,cell_biology

Species

human

Target Sentence

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. PARG is found in many tissues and may be subject to proteolysis generating smaller, active products [taken from NCBI Entrez Gene (Gene ID: 8505)].

UniGene ID

Hs.535298

UniProt ID (eCommerce)

Q86W56

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.