human LMO2 shRNA silencing AAV

Name
AAV-h-LMO2-shRNA

Cat No
shAAV-214037

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human LMO2.

shAAV-214037

AAV-h-LMO2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LMO2 (LIM domain only 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RBTN2; RBTNL1; RHOM2; TTG2

Description (Vector)

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

4005

Gene Name (Vector)

LIM domain only 2

Gene Symbol

LMO2

HGNC ID

HGNC:6642

ORF Size (aa)

456

RefSeq ID

NM_005574

RefSeq Synonyms

NM_005574, NM_001142316, NM_001142315, BC073973, BC042426, BC035607, BC034041,

Species

human

UniGene ID

Hs.716597

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.