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human LILRB4 shRNA silencing AAV

Name 
AAV-h-LILRB4-shRNA
Cat No 
shAAV-213937
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LILRB4.

shAAV-213937
AAV-h-LILRB4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LILRB4 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD85K; HM18; ILT3; LILRB5; LIR-5; LIR5;
Description (Vector)
LILRB4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
11006
Gene Name (Vector)
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Gene Symbol
LILRB4
HGNC ID
HGNC:6608
ORF Size (aa)
1347
ORF Size (bp)
1347 bp
RefSeq ID
NM_006847
RefSeq Synonyms
NM_006847, NM_001278430, NM_001278429, NM_001278428, NM_001278427, NM_001278426, NM_001081438, BC026309,
Species
human
UniGene ID
Hs.67846

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.