human KRT18 shRNA silencing AAV

Name
AAV-h-KRT18-shRNA

Cat No
shAAV-213382

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human KRT18.

shAAV-213382

AAV-h-KRT18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KRT18 (keratin 18). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

cell proliferation-inducing gene 46 protein; CK18; CK-18; CYK18; cytokeratin 18; Cytokeratin-18; K18; keratin 18, type I; keratin, type I cytoskeletal 18; Keratin-18

Description (eCommerce)

Cytokeratin 18 is a type I intermediate filament. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. [taken from NCBI Entrez Gene (Gene ID: 3875)].

Description (Vector)

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Gene ID

3875

Gene Name (eCommerce)

keratin 18

Gene Name (Vector)

keratin 18

Gene Symbol

KRT18

HGNC ID

HGNC:6430

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1293

ORF Size (bp)

1293 bp

Protein Name (eCommerce)

Keratin, type I cytoskeletal 18

RefSeq ID

NM_000224

RefSeq Synonyms

NM_199187, NM_000224, BC072017, BC020982, BC008636, BC004253, BC000698, BC000180,

Research Areas

Apoptosis,Cancer,Cell Cycle,EGFR Signaling,Golgi Apparatus,Host-Virus Interactions,Signal Transduction

Research Areas (Faceted)

cancer,cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction

Species

human

Target Sentence

Cytokeratin 18 is a type I intermediate filament. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. [taken from NCBI Entrez Gene (Gene ID: 3875)].

UniGene ID

Hs.406013

UniProt ID (eCommerce)

P05783

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.