human KLHDC5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KLHL42.
shAAV-213216
AAV-h-KLHDC5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KLHL42 (kelch like family member 42). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Ctb9; cullin-3-binding protein 9; kelch domain containing 5; kelch domain-containing protein 5; kelch-like protein 42; KLHDC5
Description (eCommerce)
Kelch-like protein 42 (KLHL42) is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P2K6].
Gene ID
57542
Gene Name (eCommerce)
kelch like family member 42
Gene Name (Vector)
kelch like family member 42
Gene Symbol
KLHL42
HGNC ID
HGNC:29252
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
Protein Name (eCommerce)
Kelch-like protein 42
RefSeq ID
NM_020782
RefSeq Synonyms
NM_020782, BC137117, BC137116, BC108669,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Kelch-like protein 42 (KLHL42) is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9P2K6].
UniGene ID
Hs.505104
UniProt ID (eCommerce)
Q9P2K6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.