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human KLHL3 Over-expression AAV

Name 
AAV-h-KLHL3
Cat No 
AAV-213249
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KLHL3.

AAV-213249
AAV-h-KLHL3

Ready-to-use AAV expressing Human KLHL3 (kelch like family member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PHA2D
Description (Vector)
KLHL3 is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
26249
Gene Name (Vector)
kelch like family member 3
Gene Symbol
KLHL3
HGNC ID
HGNC:6354
ORF Size (aa)
906
ORF Size (bp)
906 bp
RefSeq ID
NM_017415
RefSeq Synonyms
NM_017415, NM_001257195, NM_001257194, BC034035,
Species
human
UniGene ID
Hs.655084

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.