human KISS1 shRNA silencing AAV

Name
AAV-h-KISS1-shRNA

Cat No
shAAV-213151

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KISS1.

shAAV-213151

AAV-h-KISS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KISS1 (KiSS-1 metastasis-suppressor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HH13; KiSS-1

Description (Vector)

KISS1 is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Gene ID

3814

Gene Name (Vector)

KiSS-1 metastasis-suppressor

Gene Symbol

KISS1

HGNC ID

HGNC:6341

ORF Size (aa)

417

RefSeq ID

NM_002256

RefSeq Synonyms

NM_002256, BC022819,

Species

human

UniGene ID

Hs.95008

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.