human KDM6A shRNA silencing AAV

Name 
AAV-h-KDM6A-shRNA
Cat No 
shAAV-212857
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KDM6A.

shAAV-212857
AAV-h-KDM6A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KDM6A (lysine demethylase 6A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; KABUK2; lysine (K)-specific demethylase 6A; lysine-specific demethylase 6A; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously-transcribed TPR gene on the X chromosome; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; UTX
Description (eCommerce)
UTX (ubiquitously transcribed X chromosome tetratricopeptide repeat protein) is a JmjC domain- and tetratricopeptide repeat (TPR) domain- containing protein. UTX functions as a histone demethylase that specifically demethylates 'Lys-27' of histone H3, It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15550].
Description (Vector)
KDM6A is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.
Gene ID
7403
Gene Name (eCommerce)
lysine demethylase 6A
Gene Name (Vector)
lysine demethylase 6A
Gene Symbol
KDM6A
HGNC ID
HGNC:12637
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4227
ORF Size (bp)
4227 bp
Protein Name (eCommerce)
Lysine-specific demethylase 6A
RefSeq ID
NM_021140
RefSeq Synonyms
NM_021140, NM_001291421, NM_001291418, NM_001291417, NM_001291416, NM_001291415, BC143278, BC143277, BC143272, BC113381, BC093868,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Neurobiology,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,transcription_translation,genetics,neurobiology,cancer,transcription_translation
Species
human
Target Sentence
UTX (ubiquitously transcribed X chromosome tetratricopeptide repeat protein) is a JmjC domain- and tetratricopeptide repeat (TPR) domain- containing protein. UTX functions as a histone demethylase that specifically demethylates 'Lys-27' of histone H3, It demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. UTX plays a central role in regulation of posterior development, by regulating HOX gene expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15550].
UniGene ID
Hs.522616
UniProt ID (eCommerce)
O15550

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.