human KCNJ11 shRNA silencing AAV

Name
AAV-h-KCNJ11-shRNA

Cat No
shAAV-212712

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KCNJ11.

shAAV-212712

AAV-h-KCNJ11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KCNJ11 (potassium voltage-gated channel subfamily J member 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BIR; HHF2; IKATP; KIR6.2; MODY13; PHHI; TNDM3

Description (Vector)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene ID

3767

Gene Name (Vector)

potassium voltage-gated channel subfamily J member 11

Gene Symbol

KCNJ11

HGNC ID

HGNC:6257

ORF Size (aa)

1173

ORF Size (bp)

1173 bp

RefSeq ID

NM_000525

RefSeq Synonyms

NM_001166290, NM_000525, BC112358, BC064497,

Species

human

UniGene ID

Hs.248141

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.